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VAS012
Small molecule compound belonging to a novel structure class of anticancer agents targeting the signaling pathway of Rho and Rho-associated coiled-coil forming protein kinase (ROCK). VAS012 is selectively cytotoxic to proliferating endothelial cells.
VAS012 References
Maruta H, Nheu TV, He H, Hirokawa Y.
Rho family-associated kinases PAK1 and rock. Prog Cell Cycle Res. 2003;5:203-10.
Aznar Benitah S, Valeron PF, Lacal JC.
ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. Mol Biol Cell. 2003 Jul;14(7):3041-54.
Kamai T, Tsujii T, Arai K, Takagi K, Asami H, Ito Y, Oshima H.
Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res. 2003 Jul;9(7):2632-41
Sahai E, Marshall CJ.
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol. 2003 Aug;5(8):711-9.