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Veglin

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Veglin is a vascular endothelial growth factor (VEGF) antisense oligonucleotide which binds VEGF A/C/D mRNA by Watson Crick base pairing, leading to mRNA degradation. Veglin therefore inhibits signaling through all three VEGF receptors, giving it a unique mechanism of action among VEGF antagonists. Veglin was discovered at the Norris Cancer Center of the University of Southern California by VasGene’s founding scientist, Parkash Gill, M.D. Blocking this pathway leads to new therapeutics for the treatment of a variety of cancers, which utilize the VEGF receptors for growth and allow new blood vessels to grow beyond a few millimeters in size.


Schematic representation of the mixed backbone formulation oligonucleotide, Veglin

Veglin References

Wu W, Shu X, Hovsepyan H, Mosteller RD, Broek D.
VEGF receptor expression and signaling in human bladder tumors. Oncogene. 2003 May 29;22(22):3361-70.

Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS.
Malignant mesothelioma growth inhibition by agents that target the VEGF and VEGF-C autocrine loops. Int J Cancer. 2003 May 1;104(5):603-10.

Shu X, Wu W, Mosteller RD, Broek D.
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol Cell Biol. 2002 Nov;22(22):7758-68.

Chau CH, Chen KY, Deng HT, Kim KJ, Hosoya K, Terasaki T, Shih HM, Ann DK.
Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation.Oncogene. 2002 Dec 12;21(57):8817-29.

Masood R, Cai J, Zheng T, Smith DL, Hinton DR, Gill PS.
Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood. 2001 Sep 15;98(6):1904-13.

Ciardiello F, Bianco R, Damiano V, Fontanini G, Caputo R, Pomatico G, De Placido S, Bianco AR, Mendelsohn J, Tortora G.
Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res. 2000 Sep;6(9):3739-47.

Masood R, Cai J, Zheng T, Smith DL, Naidu Y, Gill PS.
Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):979-84.